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Mazatec shamans crush the leaves to extract leaf juices from about 20 to 80 (about 50g/2 oz to 200g/7 oz.) or more fresh leaves. They usually mix these juices with water to create an infusion or 'tea' which they drink to induce visions in ritual healing ceremonies.[15]

Chewing and swallowing a large number of fresh leaves is the other Mazatec method.[67][68] Oral consumption of the leaf makes the effects come on more slowly, over a period of 10 to 20 minutes. The experience, from the onset of effects, lasts from about 30 minutes up to one and a half hours.[69]

Doses for chewing vastly exceed doses used for smoking. By calculating the concentrations per leaf ("an average concentration of 2.45 mg per gram" of leaf[70]), the average weight per leaf ("about 50 g" per 20 leaves, or 2.5g/leaf[71]), and the standard dose for chewing (about 8-28 leaves[67]), the doses can range from about 50 mg to 172 mg (a few to many times more salvinorin A than consumed when smoking).